Shane  
Good morning. 
Tagging you again in case you missed the initial task. 

Chris Whenever you change targeting I have a script that goes absolutely crazy with alerts. I set it up to help catch any geo-targeting issues based on things we've dealt with in the past. It also resets all the bidding algorithms when this happens. Would be much smoother on my end to just set up a task for that vs changing active campaigns. This is likely to significantly impact performance in the areas that have been performing well as they will suddenly be flooded with budget. 

Last 30 days on Always Beautiful they have spent <10% of their budget on Search Partners. This has yielded 4 leads with a CPA of almost half what they get in Google Search. For ecommerce sites, I don't care for Search Partners. But for most of our clients that only care about leads reported, they should be left on.  The Guardian would be an example of a search partner site.

Chris  tagging you since Shane did not so you can see - read - his response. 
Shane, thanks for the detailed feedback and explanation. 

Hey guys, this change is definitely what caused the performance drop. I tried to undo the changes on Google. Let's not change any live campaigns without running it by me please. Thanks!

Shane, I have sent your observations to Chris. 
Thanks.